Large prebiotic molecules in space: photo-physics of acetic acid and its isomers

An increasing number of large molecules have been positively identified in space. Many of these molecules are of biological interest and thus provide insight into prebiotic organic chemistry in the protoplanetary nebula. Among these molecules, acetic acid is of particular importance due to its structural proximity to glycine, the simplest amino acid. We compute electronic and vibrational properties of acetic acid and its isomers, methyl formate and glycolaldehyde, using density functional theory. From computed photo-absorption cross-sections, we obtain the corresponding photo-absorption rates for solar radiation at 1 AU and find them in good agreement with previous estimates. We also discuss glycolaldehyde diffuse emission in Sgr B2(N), as opposite to emissions from methyl formate and acetic acid that appear to be concentrate in the compact region Sgr B2(N-LMH).Comment: 8 pages, 5 figure

Thermal Balancing Policy for Streaming Computing on Multiprocessor Architectures

As feature sizes decrease, power dissipation and heat generation density exponentially increase. Thus, temperature gradients in Multiprocessor Systems on Chip (MPSoCs) can seriously impact system performance and reliability. Thermal balancing policies based on task migration have been proposed to modulate power distribution between processing cores to achieve temperature flattening. However, in the context of MPSoC for multimedia streaming computing, where timeliness is critical, the impact of migration on quality of service must be carefully analyzed. In this paper we present the design and implementation of a lightweight thermal balancing policy that reduces on-chip temperature gradients via task migration. This policy exploits run-time temperature and load information to balance the chip temperature. Moreover, we assess the effectiveness of the proposed policy for streaming computing architectures by analyzing deadlines misses and architectural thermal effects of task migration using a cycle-accurate thermal-aware emulation infrastructure. Our results using a real-life software defined radio multitask benchmark show that our policy achieves thermal balancing while keeping migration costs bounded

Call me by my name: unravelling the taxonomy of the gulper shark genus Centrophorus in the Mediterranean Sea through an integrated taxonomic approach

The current shift of fishery efforts towards the deep sea is raising concern about the vulnerability of deep-water sharks, which are often poorly studied and characterized by problematic taxonomy. For instance, in the Mediterranean Sea the taxonomy of genus Centrophorus has not been clearly unravelled yet. Since proper identification of the species is fundamental for their correct assessment and management, this study aims at clarifying the taxonomy of this genus in the Mediterranean Basin through an integrated taxonomic approach. We analysed a total of 281 gulper sharks (Centrophorus spp.) collected from various Mediterranean, Atlantic and Indian Ocean waters. Molecular data obtained from cytochrome c oxidase subunit I (COI), 16S ribosomal RNA (16S), NADH dehydrogenase subunit 2 (ND2) and a portion of a nuclear 28S ribosomal DNA gene region (28S) have highlighted the presence of a unique mitochondrial clade in the Mediterranean Sea. The morphometric results confirmed these findings, supporting the presence of a unique and distinct morphological group comprising all Mediterranean individuals. The data strongly indicate the occurrence of a single Centrophorus species in the Mediterranean, ascribable to C. cf. uyato, and suggest the need for a revision of the systematics of the genus in the area

Prognostic Factors for Overall Survival In Chronic Myeloid Leukemia Patients: A Multicentric Cohort Study by the Italian CML GIMEMA Network

An observational prospective study was conducted by the CML Italian network to analyze the role of baseline patient characteristics and first line treatments on overall survival and CML-related mortality in 1206 newly diagnosed CML patients, 608 treated with imatinib (IMA) and 598 with 2nd generation tyrosine kinase inhibitors (2GTKI). IMA-treated patients were much older (median age 69 years, IQR 58-77) than the 2GTKI group (52, IQR 41-63) and had more comorbidities. Estimated 4-year overall survival of the entire cohort was 89% (95%CI 85.9-91.4). Overall, 73 patients (6.1%) died: 17 (2.8%) in the 2GTKI vs 56 (9.2%) in the IMA cohort (adjusted HR=0.50; 95% CI=0.26-0.94), but no differences were detected for CML-related mortality (10 (1.7%) vs 11 (1.8%) in the 2GTKIs vs IMA cohort (sHR=1.61; 0.52-4.96). The ELTS score was associated to CML mortality (high risk vs low, HR=9.67; 95%CI 2.94-31.74; p<0.001), while age (per year, HR=1.03; 95%CI 1.00-1.06; p=0.064), CCI (4-5 vs 2, HR=5.22; 95%CI 2.56-10.65; p<0.001), ELTS score (high risk vs low, HR=3.11; 95%CI 1.52-6.35, p=0.002) and 2GTKI vs IMA (HR=0.26; 95%CI 0.10-0.65, p=0.004) were associated to an increased risk of non-related CML mortality. The ELTS score showed a better discriminant ability than the Sokal score in all comparisons

Fine Mapping of Five Loci Associated with Low-Density Lipoprotein Cholesterol Detects Variants That Double the Explained Heritability

Peer reviewe

Queue-based scheduling for soft real time applications

Best Paper Awar

Design Guidelines for an Enhanced Interaction Experience in the Domain of Smartphone-Based Applications for Sport and Fitness

Nowadays, several research studies point up that an active lifestyle is essential for physical and mental health benefits. Mobile phones have greatly influenced people’s habits and attitudes also in the way they exercise. Our research work is mainly focused on investigating how to exploit mobile technologies to favour people’s exertion experience. To this end, we developed an exertion framework users can exploit through a real world mobile application, called BLINDED, designed to act as a virtual personal trainer to support runners during their trainings. In this work, inspired by both previous findings in the field of interaction design for people with visual impairments, feedback gathered from real users of our framework, and positive results obtained from two experimentations, we present some new interaction facilities we designed to enhance the interaction experience during a training. The positive obtained results helped us to derive some interaction design recommendations we believe will be a valid support for designers of future mobile systems conceived to be used in circumstances where there are limited possibilities of interaction

An e-coaching ecosystem: design and effectiveness analysis of the engagement of remote coaching on athletes

Nowadays, the use of mobile applications and wearable technologies to support and encourage an active lifestyle has become widespread. Several studies put in evidence that the usage of these kinds of support has to be monitored by high-qualified figures, to favor a safe and a long-term adherence to training routines. In order to investigate the impact of these professionals, this work sets out to provide an overview and an evaluation of an e-coaching ecosystem specifically designed for runners. The platform supports and guides people towards an active lifestyle by stimulating their motivation to exercise through the engagement provided by the interactions between users and human trainers. In this study, we investigate the effectiveness of the support offered by the human trainers and the engagement of the users. The results show that the support of human qualified trainers is crucial. Users tend to be more engaged to train when their trainings are developed and remotely supervised by a human coach. This has resulted in more workout sessions performed with respect to users exercising by following standard or self-made routines without direct professional supervision. Our findings show that e-coaching systems should develop their coaching protocols always taking into account the effectiveness of the support of qualified professionals over completely automated approaches